About RECTIV RECTIV—for the treatment of moderate to severe pain associated with chronic anal fissure. RECTIV, a nitroglycerin ointment, is the only FDA-approved medicine for the treatment of moderate to severe pain from chronic anal fissure. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. This medicine is for rectal use only. Do not get it in your eyes, nose, mouth, or vagina. Do not change how you use nitroglycerin ointment to avoid these headaches. Talk with your doctor for ways to lessen this side effect. Talk with your doctor for ways to lessen this side effect. These are not all of the side effects that may occur. How long can I use nitroglycerin ointment 0.2% for anal fissures. I have been using it 2 or 3 times a day for 7 months. Does it start to thin the skin where I am using it. My fissures still arnt healed. Is there something else I can use that's better for long term or is the Nytroglycerin ointment okay for long term use. thank you. However, extended use of this form of nitroglycerin is known to induce tolerance to its own beneficial actions within 12 to 24 hours,” said Cooke, adding that researchers don’t yet know the full effects of using the drug for more than 24 hours. Uses. Nitroglycerin ointment is used to treat moderate to severe pain caused by long-term tears in the lining of the anus (anal fissures). This medication works by relaxing the muscles around the. How to use Nitroglycerin. Take this medication by mouth, usually 3 to 4 times daily or as directed by your doctor. It is important to take the drug at the same times each day. Objectives. The objective of this study is to compare the difference in outcome between open partial lateral anal sphincterotomy and application of topical 0.2% nitroglycerin ointment for the treatment of chronic anal fissure. Applies to nitroglycerin: buccal tablet extended release, intravenous solution, oral capsule extended release, rectal ointment, sublingual powder, sublingual spray, sublingual tablet, transdermal film extended release, transdermal ointment Before applying a new application of nitro ointment, you must first remove the old application paper (use gloves for this) and wipe off any excessive amount of nitro left behind.